Amrita (Nargund) Mangvedhekar is a Senior Scientist in Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center.

Amrita’s research focuses on finding tumor suppressors involved in modulating clear cell renal cell carcinoma metastasis and response to immunotherapy. To better understand the role of the highly mutated tumor suppressors VHL and PBRM1, she developed a Vhl-/-; Pbrm1-/- ccRCC disease mouse model (published: Cell Reports, 2017). She further determined the aberrant targeting of PBRM1-deficient PBAF complexes to genomic loci leading to NF-κB activation and tumorigenesis (In press: Nature Cell Biology, 2023). 

Prior to moving into the field of kidney cancer, Amrita studied the mechanism of regulation of mitochondrial unfolded protein response (UPRmt) and how it preserves mitochondrial function during stress by re-routing metabolism (Published: Science, 2012 and Molecular Cell, 2015), which was funded by Kirschstein National Research Service Award (NRSA F32).